每日摄入醋可改善健康成年人的抑郁评分并改变其代谢组：一项随机对照试验

2023年11月11日 

https://pmc.ncbi.nlm.nih.gov/articles/PMC8622118/

摘要
每日摄入醋与改善血糖控制有关，但近期数据表明，醋在心理健康方面可能具有尚未被充分探索的作用。本研究采用安慰剂对照、平行组设计，为期4周，旨在探讨每日摄入醋对健康大学生情绪状态和尿液代谢物的影响。参与者被随机分配至醋组（VIN组：n = 14；每日摄入1.5克醋酸，以液体醋的形式）或对照组（CON组：n = 11；每日服用0.015克醋酸片剂），两组参与者的日常饮食和运动量均保持不变。在基线和研究的第四周，参与者完成了情绪状态量表（POMS）和流行病学研究中心抑郁量表（CES-D）问卷，并提供了晨尿样本用于靶向代谢组学分析。四周后，POMS抑郁评分和CES-D评分的变化在各组间存在显著差异，VIN组参与者的情绪改善优于CON组。干预前后的代谢组学分析表明，摄入醋与改善情绪相关的代谢物改变一致，包括己糖胺途径的酶功能障碍以及甘氨酸、丝氨酸和苏氨酸代谢的显著增加。这些数据表明，醋作为改善情绪状态的潜在药物值得进一步研究。

结论：

在受控条件下，健康大学生每日摄入苹果醋（2汤匙；5%酸度）四周后，抑郁评分降低。干预前后的代谢组学分析表明，摄入醋与改善情绪相关的代谢物改变一致。超过40%的大学生自述患有中度至重度抑郁症，较过去十年增长了77%[48]，因此迫切需要简单安全的策略来有效缓解这一人群的抑郁症状。这些数据表明，有必要继续研究醋作为改善情绪状态的潜在作用。

Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial
Nov 11 2023

https://pmc.ncbi.nlm.nih.gov/articles/PMC8622118/ 

Abstract
Daily vinegar ingestion has been linked to improved glycemic control, but recent data suggest a separate unexplored role for vinegar in mental health. Utilizing a placebo-controlled, parallel arm study design, this 4-week trial examined the impact of daily vinegar ingestion on mood states and urinary metabolites in healthy college students. Participants were randomized to the vinegar group (VIN: n = 14; 1.5 g acetic acid/day as liquid vinegar) or the control group (CON: n = 11; 0.015 g acetic acid/day as a pill) with no change to customary diet or physical activity. At baseline and at study week four, participants completed the Profile of Mood States (POMS) and the Center for Epidemiological Studies-Depression (CES-D) questionnaires and provided a first-morning urine sample for targeted metabolomics analyses. The change in both POMS depression scores and CES-D scores differed significantly between groups favoring improved affect in the VIN versus CON participants after four weeks. Metabolomics analyses pre and post-intervention suggested metabolite alterations associated with vinegar ingestion that are consistent for improved mood, including enzymatic dysfunction in the hexosamine pathway as well as significant increases in glycine, serine, and threonine metabolism. These data warrant continued investigation of vinegar as a possible agent to improve mood state.
Conclusion
The daily apple cider vinegar ingestion (2 tablespoons; 5% acidity) lowered depression scores in healthy college students under controlled conditions after four weeks. Metabolomics analyses pre- and post-intervention suggest metabolite alterations associated with vinegar ingestion that are consistent for improved mood. With over 40% of college students self-reporting moderate-to-severe depression, a 77% increase over the past decade [48], simple and safe strategies that effectively reduce depression in this population are urgently needed. These data warrant continued investigation of vinegar as a possible agent to improve mood state.